I have Windows Defender (MSE for Windows 8) on my Atom based tablet and I don't notice it running.
I used to have to run a fleet of Athlon 2000+ PCs with 256MB RAM (2009/2010) and they had had Symantec's corporate suite installed on them a couple of years earlier by the previous admin, but he had never run a scan and real-time scanning was disabled, because it made the hardware unusably slow! I ran a scan on one machine, the machine couldn't be used for anything else for 48 hours!
I switched to GData and I forced every PC to perform a scan, it found a few thousand infected files, even though they swore that the network was clean! One virus was particularly bad and I would have had to close one of the sites down for a whole weekend and remove every machine from the network and only re-attach and patch them, once the virus had been removed. Between cleaning and patching, if there was another infected machine on the network, the clean PC would be reinfected!
I never got permission to clean the site...