I ordered some liquid from The One Pound Liquid Website on Tuesday and they were delivered yesterday. Ten bottles for £11.50, including postage, and the reviews seem good. I will be doing my own reviews on their site, but am happy to post them here, if anybody is interested.

I ordered the following flavours, by the way.

Cappuccino - 10ml
Banana - 10ml
Strawberry Milkshake - 10ml
Peach - 10ml
Rhubarb & Custard - 10ml
Vanilla Custard - 10ml
Lemon Sherbet - 10ml
Strawberry & Lime - 10ml
Choc-a-Nana - 10ml
Blackcurrant & Liquorice - 10ml

Bought the Innokin Cool Fire IV today, and an iClear 30s to go with it. First impressions are that it's very good. I'll have a read of the user guide later, to see the power options, but so far I am impressed.

OK - so serious question here, which has been partly prompted by a discussion on FaceBook, but has also been playing around my mind again recently.

As you will know, I’m asthmatic, and I’ve been through a whole load of different kinds of inhalers, and I’ve even been put on a nebuliser a few times in the past. A nebuliser is a nice medical word for a device that turns a liquid into a vapour. I’ve said before that I think that vaping may well indicate a direction of asthma treatment that’s been ignored. The devices that are basically electric pipes - the kind which look like small iPods with a mouth piece - are the kind I’m thinking of as they seem to do the same job. They turn a liquid containing a drug into a vapour, which is then inhaled and absorbed in the lungs. If the experience is anything like using a nebuliser, I’d expect that the take up of the drug is pretty quick.

So, this brings me to dosing. In asthma inhalers, you get either the kind that’s propelled (aerosol) or the kind where the drug is in a powder, and breathing in is the only power it needs. The latter is, in my experience, more effective, but I feel that there is still wastage. Whichever you use, you get a fair amount hitting the back of the throat.

This brings me to the vaping things. How do you regulate dosage? If these were repurposed into a device to deliver a known quantity of a drug, then you would need to ensure that that’s the exact amount that’s taken. So, let’s assume that for one minute that 1 cigarette = 1 dose of nicotine, how would you get that same amount in with a vaping machine? The nebulisers have a phial that you put into the mouthpiece, and as the air is blown over or through it, a vapour is created and once it’s empty, that’s 1 dose. However, I am guessing that with a vaping device, your reservoir contains possibly more than one cigarette’s amount of nicotine, and as long as it’s in a concentration that doesn’t mean you’ll over dose on the stuff, you inhale when you need to. It also means that improved efficiency of absorption may men that you need less of the drug in the first place, which is no bad thing (some asthma medicine has scary side effects)

This doesn’t mean that I’m going to pillage my inhalers and experiment with a vaping machine, but I see enough similarities to think that if dosage can be tightly controlled, then you have something with the potential to be a very effective form of asthma treatment, and something that could reduce the size of emergency equipment by about 90%.

Regulating dosage is a bit of a manual process in vaping.
You pick your nicotine percentage in the liquid then the volume of liquid in the tank is dependant really just on the size of the tank.
It's up to the end user to decide if they want to vape the whole tank or space it out over the day/week etc.

With nicotine you soon know if you're vaping too much as you get "nic sick" but that comes down to just using a bit of common sense.

Now in theory (disclaimer: this is just an opinion with no scientific testing etc) you could put a measured amount of the solution in to a disposable tank with instructions that it's to be used all in one session, then attach that to a traditional vaping device and you're set.
You can use electronics to measure puffs etc (these exist already) or to monitor the volume in the liquid, pumps can be used to make a device constantly produce vapour etc

I'd be extremely surprised if this sort of thing hasn't been looked at already.
Pharmaceutical companies do A LOT of research into delivery methods.

I suspect the main issue with a conventional vaping machine that relies on heat to get the active substance into a vapour form is the effect of the heat on the drug molecule.
With something like Nicotine, it's a relatively small molecule and it's pretty stable to heat (otherwise smoking really wouldn't work as a delivery mechanism).
Generally speaking the drugs used for treating asthma are bigger and less thermally stable than Nicotine so getting them hot enough to vaporise (even in a solvent) is more likely to make the molecule fall to bits.
In addition, they may not be terribly water soluble so would require the use of a suitable, non-toxic, organic solvent which may or may not add it's own problems.

Here's Nicotine (left) and Salbutamol (right) as examples:


It's been a while since I did organic chemistry but off the top of my head I'd expect the salbutamol to break apart at the nitrogen atom or undergo some sort of rearrangement if you heated it up in the presence of water.

Got myself an Innotek Coolfire IV at the weekend. Very pleased.

I'm smoking fruit pastilles!

Sent from my Lumia 830 running Windows 10

Don't they go a bit dibbley when they melt?

I've had one of them for a few months, and it's proving to be a really good buy. Running mine with an iClear 30s until I get around to rebuilding my Kayfun Lite. What's on yours?

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It's sporting an Aspire Mini Nautilus - I'm told that's good

I had to go look tbh - I just turned up at Smokey Joes in Rugby and they just sorted me out with decent kit