Potentially, yes. That's why the North East voted against a devolved administration with next to no real power a while back and why Manchester voted against having an elected Mayor - a vote which the government is now ignoring and imposing an unelected mayor (!) for the next two years before an election happens which will probably make the police commissioner elections look popular.
However, if there's actual reorganisation of the chain of democracy in the UK and the regions are given actual powers it might be a god thing. Of course, pigs might fly.
And how will that help devolve power away from Westminster to the regions exactly?